Medicines

New therapeutics across multiple diseases

THE CELLARITY ATLAS

  • GI Cellarity Map
  • T cell exhaustion Cellarity Map
  • Lung Cellarity Map
  • Adipocyte Cellarity Map
  • Hematology Cellarity Map

We have developed Cellarity Maps for a variety of disease conditions to understand how cell behavior changes in a disease state compared to a healthy state. As we continue to map and reveal how cell behavior changes, we further gain a clearer picture of biology from the cell-centric lens. Armed with this knowledge, we can design new Cell Behavior Targeted medicines in a wide variety of diseases.

We have demonstrated our precise ability to change the behaviors of disease in 10 different therapeutic areas. We have already produced a number of compounds that trigger that change and confirmed their activity through in vitro and in vivo models of disease. This work is strengthening our proprietary understanding of how cell behavior manifests in disease and how to specifically impact it at the cellular level to reverse disease.

At this time, we are progressing a number of validated programs in 4 high value disease areas to develop breakthrough medicines for patients in need. Our current areas of focus are:

  • Hematology
  • Immuno-oncology
  • Metabolism
  • Respiratory

LIMITLESS APPLICATIONS

Our cell-centric approach to drug design is a generalizable process through which Cellarity Maps guide the prediction of interventions that can change cell behaviors to treat a diverse array of diseases.

We no longer need to reduce disease biology to a single causal target in order to create medicines. Instead, we harness the complexity of biology by digitally predicting molecules that will change cell behaviors. In this way, our algorithms are capable of identifying drug candidates that might otherwise be undiscoverable.

Cell behaviors are far better representations of disease than individual proteins, so this approach is more likely to produce breakthrough therapies with better clinical predictability.